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KMID : 0525720080130010040
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Journal of Chitin and Chitosan
2008 Volume.13 No. 1 p.40 ~ p.47
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pH-Responsive Hydrogels Composed of Chitosan and Poly(γ-Glutamic acid) by EDC/NHS cross-Linking for Controlled Drug Release : Preparation, Characterization and Drug Release Behavior
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Park Bo-Gi
Kim Koo-Youn
Kim Kwang-Il
Son Tae-Il
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Abstract
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pH-sensitive hydrogels composed of Chitosan and Poly(γ-Glutamic acid) (γ-PGA) were prepared by the freeze drying method and EDC/NHS cross-linked to suppress the deformation of hydrogel in water. The physical properties, swelling and drug diffusion behaviors were characterized for the hydrogels. In equilibrium swelling study, Chitosan/γ-PGA hydrogels shrunk in pH resions below pKa(2.27) of γ-PGA whereas they swelled above pKa. In the drug diffusion study, the drug permeation rates of Chitosan/γ-PGA hydrogels were directly proportional to their swelling behaviors. The cytocompatibility test showed no cytotoxicity of Chitosan/γ-PGA hydrogels for the NIH 3T3 cell lines. The results of above studies suggest that the hydrogels prepared from Chitosan and γ-PGA can be utilized as an orally administrable drug delivery system.
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KEYWORD
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Hydrogels, Swelling, Drug delivery systems, EDC/NHS cross-Linking
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